Synthesis of pyrazine alcaloids from Botryllus leachi. Diazines 43.

نویسندگان

  • Frédéric Buron
  • Nelly Plé
  • Alain Turck
  • Guy Queguiner
چکیده

[reaction: see text] Regioselective metalation of pyrazines and cross-coupling reactions provides an easy access to botryllazines A and B and to an isomer of botryllazine A with good yields from chloropyrazine.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The developmental cycle of Botrylloides.

OF the many studies made on ascidians in the past, few have included the organism in its entirety. The present account is of the whole developmental cycle of an organism exhibiting exquisite timing in its four-dimensional relationships, with an interpretation of a colonial organism as the result of a few interacting processes. A comparison of Botrylloides with Botryllus affords some analysis of...

متن کامل

Nuclear-Chemical Synthesis of 1,4-Diazine Quaternary Salts

Ion-molecular reactions of nucleogenic phenyl cations with the nucleophilic centers of 1,4-diazines have been investigated for the first time. Previously unknown tritium labeled N-phenyl quaternary derivatives of pyrazine and quinoxaline, which are potential radioactive biomarkers, have been obtained by nuclear-chemical method.

متن کامل

Synthesis and Evaluation of Pyrazine Derivatives with Herbicidal Activity

The pyrazine ring is a part of many polycyclic compounds of biological and/or industrial significance; examples are quinoxalines, phenazines, and bio-luminescent natural products pteridines, flavins and their derivatives. All these compounds are characterized by a low lying unoccupied π-molecular orbital and by the ability to act as bridging ligand. Due to these two properties 1,4-diazines, and...

متن کامل

Transforming LiTMP Lithiation of Challenging Diazines through Gallium Alkyl Trans‐Metal‐Trapping

This study establishes a new trans-metal-trapping (TMT) procedure based on a mixture of LiTMP (the base) and tris(trimethylsilylmethyl)gallium [Ga(CH2 SiMe3 )3 , GaR3 ] (the trap) that, operating in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hydrocarbon solution, as illustrated through reactions of pyrazine, pyridazine, and pyrimidine, as well as...

متن کامل

Rediscovering the Wheel. Thermochemical Analysis of Energetics of the Aromatic Diazines.

Thermochemical properties of pyrimidine, pyrazine, and pyridazine have been measured and re-evaluated to provide benchmark quality results. A new internally consistent data set of ΔfHm°(g) has been obtained from combustion calorimetry and vapor pressure measurements. The gas and condensed phase enthalpies of formation of the parent diazines have been re-evaluated, and the results were compared ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of organic chemistry

دوره 70 7  شماره 

صفحات  -

تاریخ انتشار 2005